Peptide library

1. SemaglutideThe Established GLP-1The most established GLP-1: about 15% weight loss, and the only one approved to reduce cardiovascular risk.Clinical trials · 16.5M claimsPrescription
2. TirzepatideThe Dual AgonistDual GLP-1 and GIP agonist: approximately 22.5% loss, FDA-approved.Clinical trials · 6.3M claimsPrescription
3. TesamorelinThe GH OptimizerThe only FDA-approved compound specifically indicated for visceral fat reduction.Clinical trials · 5,399 claimsPrescription

How this was measured. US Medicare Part D and Medicaid claims, data year 2024, the most recent published. Semaglutide 16.5 million claims, tirzepatide 6.3 million, tesamorelin 5,399. Excludes commercial insurance and cash-pay, which is where most weight-management prescribing sits. The data lags by about eighteen months, and it lags through the period in which tirzepatide grew fastest, so tirzepatide is understated here.

1. RetatrutideThe Triple AgonistInvestigational triple agonist: the largest weight reduction recorded in trials.Clinical trials · 496 postsNo approved product
2. GHK-CuThe Copper PeptideCopper-binding tripeptide with small human studies on skin, and none yet by injection.Small human studies · 363 posts
3. BPC-157The Repair SignalGastric-derived peptide studied for tendon, muscle, ligament and gut repair.Preclinical + practitioner use · 241 posts
4. CJC-1295 (no DAC)The Short PulseA GHRH analog used to produce short GH pulses, usually paired with a GHRP.Small human studies · 149 posts
5. MOTS-CThe Mitochondrial PeptideA mitochondria-encoded peptide that activates the same energy switch as exercise.Preclinical + practitioner use · 148 posts
6. TB-500The Repair CrewA lab-made fragment of thymosin beta-4. Its parent protein has been studied in wound healing; TB-500 itself has no human data.Practitioner experience only · 116 posts
7. IpamorelinThe Clean PulseDescribed in our sources as the most selective GH secretagogue: no cortisol, prolactin or appetite spike.Small human studies · 87 posts
8. KPVThe Inflammation TripeptideThree-amino-acid α-MSH fragment used for gut and skin inflammation.Preclinical + practitioner use · 81 posts
9. SemaxThe Russian NootropicHeptapeptide with Russian stroke-rehabilitation data, used off-label for cognition.Small human studies · 77 posts
10. SelankThe AnxiolyticAn anxiolytic peptide studied for stress-related sleep disruption.Practitioner experience only · 60 posts

How this was measured. US Google Trends over the twelve months to August 2026, and 2,077 posts counted across r/Peptides, r/peptidesource and r/PeptideStacks in August 2026. Attention is not use, and it is certainly not evidence of benefit or safety. Several compounds high on this list have no human data at all. Read each record before you read this ordering as a recommendation, because it is not one.

• DSIPThe Sleep ResetA neuropeptide studied for deep, delta-wave sleep: depth, not sedation.Small human studies
• Pentadeca arginateBPC-157, Different SaltThe same 15-amino-acid peptide as BPC-157, supplied as an arginine salt.Practitioner experience only
• Thymosin alpha-1The Immune ModulatorThe best-evidenced immune peptide here, and it is not FDA-approved.Clinical trials
• PT-141The Desire DrugFDA-approved for premenopausal HSDD. Narrow indication, real side effects.Clinical trialsPrescription
• OrforglipronThe Oral GLP-1The first approved oral GLP-1, and it is not a peptide.Clinical trialsPrescription
• SS-31 / ElamipretideThe Cardiolipin BinderThe first approved therapy for a mitochondrial disease, sold for longevity at a fraction of the approved dose.Clinical trialsPrescription
• NAD+ (injectable / IV)The Clinic DripThe highest-volume wellness-clinic infusion, with no outcomes trial behind it.Practitioner experience only
• Larazotide acetateThe Gut-Barrier Drug You Cannot BuyZonulin receptor antagonist. Phase 3 terminated early; not purchasable.Clinical trialsNo approved product
• Thymosin β4 (full length)The Molecule TB-500 Is NotThe full 43-amino-acid protein with real trials, and it is not TB-500.Clinical trialsNo approved product
• LL-37The Antimicrobial PeptideHuman antimicrobial peptide. FDA wrote a stronger warning for it than for any peer.Small human studies
• Melanotan IIThe Tanning PeptideTanning and libido peptide with documented case-report harms. We publish no dose.Practitioner experience only
• Methylene blueThe Serotonin Syndrome RiskNot a peptide. Approved for methemoglobinemia, and it carries a boxed warning.Clinical trialsPrescription
• CagrilintideThe Amylin Half of CagriSemaLong-acting amylin agonist. Investigational alone; studied as half of CagriSema.Clinical trials
• Kisspeptin-10The Four-Minute PeptideThe famous HSDD trials used kisspeptin-54. This is kisspeptin-10.Small human studies
• OxytocinThe Bonding HormoneIntranasal oxytocin: 38 RCTs, good safety data, and no detectable subjective effect.Small human studiesPrescription
• HexarelinThe One With The Cortisol ProblemThe third GHRP, and the one that also raises cortisol and prolactin.Small human studies

• EpitalonThe Telomere CourseA tetrapeptide studied for telomerase activation and pineal melatonin support.Preclinical + practitioner use
• GHRP-2The Selective GHRPA ghrelin-receptor GH releaser with less appetite stimulation than GHRP-6.Practitioner experience only
• GHRP-6The Hungry OneA strong GH releaser that also raises appetite, cortisol and prolactin.Small human studies
• SermorelinThe Gentle GHRHA GHRH analog producing a milder GH bump than tesamorelin.Small human studiesNo approved product
• MK-677The Oral SecretagogueAn oral GH secretagogue producing sustained rather than pulsatile elevation.Small human studies
• AOD-9604The GH FragmentA growth hormone fragment studied for lipolysis, with mixed human data.Small human studies
• Matrixyl 3000The Signal PeptideA topical signal peptide that triggers fibroblast collagen production.Practitioner experience only
• ArgirelineThe Expression Line PeptideA topical neurotransmitter peptide aimed at expression lines.Practitioner experience only
• Bacteriostatic WaterThe SolventUSP-grade sterile water with 0.9% benzyl alcohol, the standard peptide diluent.Clinical trials
• SurvodutideThe Estimand LessonGlucagon/GLP-1 dual agonist. Not approved anywhere; the numbers depend on the question.Clinical trials
• MazdutideApproved In ChinaGlucagon/GLP-1 dual agonist approved in China, not by FDA.Clinical trials
• TesofensineNot A Peptide, Not A GLP-1An oral CNS triple reuptake inhibitor sold through peptide vendors.Small human studiesNo approved product
• 5-Amino-1MQZero Human TrialsOral NNMT inhibitor. Small molecule, not a peptide, and no human trials exist.Practitioner experience only
• SLU-PP-332The Detection Assay CompoundPan-ERR agonist with no human programme. Its 2026 literature is doping detection.Practitioner experience only
• HGH Fragment 176-191The AOD-9604 RelativeThe unmodified fragment AOD-9604 was built from. Same failed premise.Practitioner experience only
• CerebrolysinGood Evidence That Says NoPorcine-brain peptide mixture. Cochrane found more non-fatal serious adverse events.Clinical trialsPrescription (non-US)
• VIP / AviptadilTwo Halves, Both RequiredThe pharma programme failed its controlled trials while the community protocol grew.Practitioner experience onlyNo approved product
• ARA-290Better Evidence, Dead ProgrammeTwo small RCTs with objective imaging endpoints, and no active trials left.Small human studies
• ThymulinThe Ten-Fold Dose SpreadZinc-dependent thymic peptide. No established human dose. We publish none.Practitioner experience only
• EcnoglutideApproved In China 2026cAMP-biased GLP-1 agonist approved in China, appearing in gray-market channels.Clinical trials
• EloralintideAmylin Alone At Twenty PercentSelective amylin agonist reaching −20% as monotherapy in Phase 2.Clinical trials
• PetrelintideThe Tolerability ContrastLong-acting amylin analogue with a ten-day half-life and a mild GI profile.Clinical trials
• BimagrumabThe Lean-Mass AnchorInvestigational ActRII antibody given intravenously every 12 weeks. Not self-administered.Clinical trials
• NMNThe Oral NAD+ PrecursorOral NAD+ precursor with real biochemical data. Not the same as injectable NAD+.Small human studies
• HumaninNo Human Dose ExistsMitochondrial-derived peptide with no human intervention trial and no dose.Practitioner experience only
• PEG-MGFNo Human Exposure DataSold for muscle and tendon repair. FDA found no human exposure data by any route.Practitioner experience only
• AfamelanotideThe Approved MelanotanMelanotan I is an approved implant for a rare disease. Melanotan II is not.Clinical trialsPrescription
• SNAP-8Argireline With Two More ResiduesTopical SNARE-interfering octapeptide. All the efficacy data is manufacturer-funded.Practitioner experience only
• Glutathione (injectable)The Endotoxin Case StudyInjected for skin lightening with no trials, and a documented endotoxin incident.Practitioner experience only
• DihexaNever Tested In HumansAngiotensin IV analogue, never tested in humans, activating a cancer pathway.Preclinical + practitioner use