No Human Dose Exists
Humanin
Also known as HN · MTRNR2 · HNG
At a glance
- What it is
- Mitochondrial-derived peptide with no human intervention trial and no dose.
- Evidence
- Practitioner experience onlyHow the tiers workThe entire 2026 humanin literature is preclinical or observational: attenuation of atrial fibrillation in an animal model alongside MOTS-c, protection of granulosa cells under oxidative stress, mitigation of amyloid-beta retinal injury via AMPK-Beclin1 mitophagy, altered placental expression in gestational diabetes as an observational biomarker, and circulating levels associating with Mediterranean-diet adherence and acute endurance exercise. Why this tier
- Half-life
- Not established in available literature
- Routes
- Subcutaneous
- Category
- Mitochondrial
- WADA
- We do not state a status
- Amino acids
- 24
Not schedulable in Claritide. Our sources publish no dosing figure for Humanin, so there is nothing to build a schedule from.
Why this tier
The entire 2026 humanin literature is preclinical or observational: attenuation of atrial fibrillation in an animal model alongside MOTS-c, protection of granulosa cells under oxidative stress, mitigation of amyloid-beta retinal injury via AMPK-Beclin1 mitophagy, altered placental expression in gestational diabetes as an observational biomarker, and circulating levels associating with Mediterranean-diet adherence and acute endurance exercise. No human intervention trial was located. No established human dose exists, and humanin is not on any FDA compounding list.
What it is
Humanin is a mitochondrial-derived peptide encoded in mitochondrial DNA, from the same family as MOTS-c. Its entire recent literature is preclinical or observational. There is no human intervention trial and no established human dose, which is the reason this record exists, so that a search for humanin lands on the page that says so.
How it works
Humanin is encoded within the mitochondrial genome rather than the nuclear one, and is described as cytoprotective: it opposes apoptosis under stress, supports mitochondrial function and modulates inflammatory signalling. Circulating levels are studied as a biomarker, associating with things like Mediterranean-diet adherence and acute endurance exercise. Observing that a peptide correlates with health is not the same as showing that administering it produces health, and for humanin the second step has never been taken in a person.
Commonly researched ranges
Not established in available literature. Our sources describe Humanin without publishing a dosing figure, so Claritide does not print one.
- Cycle guidance
- Not established in available literature
- Goals
- Longevity, Energy
Where this sits with the FDA
Humanin does not appear on FDA’s compounding category lists as of August 2026. That is neither a permission nor a warning: it means nobody has nominated it for assessment.
Primary sourceWADA status
Not named on the 2026 Prohibited List. We could not determine a classification and do not state one.
We looked and could not resolve it. This is not the same as "not prohibited". Treat it as unresolved and check with your federation before competing.
Mixing recipes our sources document
Not established in available literature. Use the calculator with the figures printed on your own vial.
Open the calculator
Week by week
Not established in available literature.
Side effects
Not established in available literature. Absence from this page does not mean absence of risk. It means our sources publish no side-effect profile for Humanin.
Contraindications and interactions
Do not use if
- There is no established human dose for humanin, so there is no dose anyone can justify
Interactions
Not established in available literature.
Absence from this list does NOT mean safety. It means lack of research.
Storage and cost
- Storage
- Our sources publish no handling protocol, because there is no human dosing protocol.
- Cost
- Not established in available literature
Stacks with
Humanin in full
Limited coverage, and that is the point of the page
Humanin is a mitochondrial-derived peptide, encoded in mitochondrial DNA, from the same family as MOTS-c. HNG is a more potent analogue.
There is no human intervention trial. There is no established human dose. We publish an empty dose range and a null half-life, and this record exists mainly so that a search for humanin lands somewhere that says so plainly.
What the 2026 literature actually contains
All of it is preclinical or observational:
- attenuation of atrial fibrillation in an animal model, studied alongside MOTS-c
- protection of ovarian granulosa cells under oxidative stress
- mitigation of amyloid-beta retinal injury through AMPK-Beclin1 mitophagy
- altered placental expression in gestational diabetes, an observational biomarker finding
- circulating levels associating with Mediterranean-diet adherence and with acute endurance exercise
Reading the biomarker studies carefully
The last item is the one most likely to be misread. Higher circulating humanin correlates with things that look like health: a good diet, exercise. It is easy to conclude that raising humanin would therefore produce those benefits.
That inference does not follow. A marker that goes up when you exercise may be a consequence of exercising, not a mechanism you can take a shortcut to. Establishing the difference requires giving humanin to people and measuring what happens, and nobody has done that.
Sources
- 1Preclinical humanin study, 2026
- 2Preclinical humanin study, 2026
Every record in this library is free to read, and it stays free. Your own schedule, vials and log live in the app: Claritide for iPhone.