Move each shot to the next of eight zones, and never use the same zone two days in a row. On a daily schedule, that gives every spot a week to recover before its next shot.
Eight zones
The Playbook's injection site rotation log defines eight subcutaneous zones:
Zone 1: Left abdomen, 2+ inches from the navel Zone 2: Right abdomen, 2+ inches from the navel Zone 3: Left thigh, outer, mid-section Zone 4: Right thigh, outer, mid-section Zone 5: Left upper arm, back/outer Zone 6: Right upper arm, back/outer Zone 7: Left love handle area Zone 8: Right love handle area
The rule
Rotate through zones sequentially. Do not inject the same zone two days in a row.
That is the whole system. Eight zones on a daily protocol means each site gets seven days to recover before it sees a needle again.
Why 2+ inches from the navel
The area immediately around the navel has different tissue structure and less reliable subcutaneous depth. The tesamorelin protocol specifically instructs rotating within the abdomen while avoiding the navel area.
What rotation is preventing
Lipodystrophy: tissue changes from repeated injection into the same spot.
Subcutaneous fat responds to repeated needle trauma. Over time, injecting the same site produces either lipohypertrophy, where the tissue thickens into a firm lump, or lipoatrophy, where it thins and dimples.
Beyond the cosmetic problem, this matters practically: absorption from scarred or thickened tissue is unpredictable. A dose injected into a lipohypertrophic site may not be the dose that reaches circulation. You lose the consistency that makes a protocol interpretable.
Logging it
The Playbook's rotation log records date, zone number, compound, dose, and notes on redness or soreness.
Two reasons to keep it. First, human memory for "which side did I use yesterday" is unreliable, especially on a daily protocol at 11 PM. Second, the notes column builds a picture: if zone 3 is consistently sore and no other zone is, that is information about your technique or your tissue, not about the compound.
Claritide's site map does this automatically, with a heat map that decays over 14 days and a next-best-site suggestion. It splits the abdomen into quadrants and carries the intramuscular sites too, so the map you tap is longer than the Playbook's eight, but it narrows itself to the zones your protocol's routes allow, and the rule underneath is the same one.
Compound-specific overrides
Rotation is the default. Two exceptions worth remembering:
BPC-157 for a musculoskeletal injury is injected near the injury site, because the effect is local. You still rotate within the available area around the injury rather than using one exact spot repeatedly.
Tesamorelin rotates within the abdominal area specifically rather than across all eight zones.
When a protocol constrains where you can inject, rotation happens inside that constraint rather than being abandoned.
The practical version
If you are on a daily protocol, go 1, 2, 3, 4, 5, 6, 7, 8, then back to 1. If you are on twice-weekly, the rotation matters less but costs nothing to maintain.
Never two days in a row in the same zone. That is the rule that does most of the work.