Running out is ordinary
Interruptions are not a rare event at the edge of this field. In a retrospective cohort of 125,474 US adults who started a GLP-1 for overweight or obesity, one-year discontinuation was 64.8% among people without type 2 diabetes and 46.5% among people with it, with discontinuation counted as sixty days with none of the drug on hand. Moderate or severe gastrointestinal side effects raised the chance of stopping; greater weight loss lowered it.
That study is about one drug class, and about stopping rather than about a fortnight's wait for a reorder. It is here for one reason: if you run out mid-cycle you are in very ordinary company, and an app that treated the gap as a moral event would be misrepresenting how common it is.
What the gap does to your data
A gap is a fact about your protocol. Record it as one.
- Answer the doses you did not take. Ran out is one of the five reasons, and it is the one that points at supply rather than at adherence.
- Doses taken puts a missed dose and a skipped one in the denominator either way, so the reason you attach is the part that carries the information.
- Signal's dosing-day comparisons lose days from the dosed side of the split and gain them on the other. That is not damage. An unplanned break is a real comparison, and it is one of the few times a log gets a genuine off-block without anybody designing one.
- The one thing that does damage is marking those doses taken. The runway, the vial's remaining volume, every outcome comparison and the physician report are all built on a taken row meaning a dose went in.
What Claritide can tell you before you get there
The inventory tool projects each open vial forward against the protocol you are actually running: the volume drawn per dose at the rung you are on now, summed across every item drawing on that vial, converted to millilitres per week and then to a date.
It flags a vial at ten days of runway and starts watching one at twenty. It shows the projected empty date and the whole doses left in the vial. Where nothing in your protocol draws on a vial it says so, rather than inventing a burn rate to fill the space.
What it cannot do is know your supplier. Claritide holds no shipping times, no vendor lead times and no stock information. There is no server and no vendor relationship here, so days of runway is the whole of what it can offer. The rest of that arithmetic is yours.
The clock the vial keeps
Reconstituted with bacteriostatic water and refrigerated, our storage matrix gives a vial 28 days, and that limit is the beyond-use date for an entered vial rather than a claim about the peptide. The clock runs on the calendar from the day you mixed it, not on how many doses you have drawn from it. A pause does not pause it. A vial that sits through a two-week supply gap comes out of the gap two weeks older.
The window matters to the record and not only to the compound: a dose from a vial three weeks past its window is not the dose you think you took, and it quietly poisons every comparison you draw afterwards.
Pausing, and what it does to the numbers
Setting a protocol to Paused stops the schedule generating new doses and clears the ones already written for days that have not arrived, so an empty fortnight cannot accumulate as a fortnight of misses. Doses that were already due are left alone. They were genuinely scheduled, and they still want an answer.
Two things do not pause with the protocol.
Stepping the dose up runs on dates, not on doses taken. A long enough gap moves your rung on its own, so the rung waiting for you on the other side may not be the one you left. The protocol page states which one it is.
The vial's beyond-use window, as above.
Resuming re-materialises the next three weeks from today, and nothing you have already logged is affected either way.
Whether to pause or carry on
Whether to pause the protocol, wait for the reorder, pick up where you left off, or treat the gap as the beginning of a break is a decision about your doses. It is not one this app makes. What it can do is make sure the record still says what actually happened.
Two things from our own material are worth having in front of you while you decide. Several compounds here are cycled by design: MOTS-C four to eight weeks on and four off, BPC-157 in four-to-six week cycles with a break before any second one. So a forced gap is sometimes indistinguishable from the plan. And what happens after stopping differs sharply by compound: some effects bank and some reverse. "When to stop", at the end of this module, covers which is which.